Tammy L. Dellovade

Conformation-specific anti-pathological tau antibody raised against AD brain-derived seed-competent tau reduces tau pathology in transgenic mice

Accumulation of intracellular hyperphosphorylated tau protein into aggregates called neurofibrillary tangles is a hallmark of Alzheimer’s disease (AD) and other neurodegenerative diseases. In AD, tau pathology spreads trans-synaptically in a defined pattern, correlating with cognitive decline. We hypothesized that anti...