Tam Truong

Translating the Crosstalk Between Unfolded Protein Response and Ferroptosis to Cancer Therapies

To survive the proteotoxic and oxidative stress that are prototypical of rapidly multiplying cells, cancer cells must successfully navigate two existential threats: the danger of protein misfolding in the endoplasmic reticulum and the peril of iron-catalyzed peroxidation of membrane lipids. Over the past few decades, t...