LP.8.1-directed recombinant protein COVID-19 vaccine S-268025, formulated with squalene-based adjuvant A-910823, elicits robust immunogenicity and neutralizing breadth in mice.
SARS-CoV-2 continues to evolve by repeatedly undergoing antigenic mutations and evolving into different lineages, evading host immunity. Currently, viruses derived from the JN.1 lineages such as XFG and NB.1.8.1 strains have continued to spread globally, and the BA.3.2.2 strain has also been detected as a new lineage t...