Author

Takashi Miki

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Open access Oct 2026

Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolism

Summary Gut microbiota act as beneficial symbionts of the hosts. Administration of α-glucosidase inhibitors (α-GIs) is considered to promote the microbiota’s carbohydrate availability, modulating short-chain fatty acid (SCFA) production. However, it remains unclear whether host-microbiota interaction differs depending...

Hayato Yoshikawa, Eunyoung Lee, Ryo Hatano et al. · iScience · 0 citations

Open access Oct 2026

GLS2 Promotes Early Ferroptosis Followed by Apoptosis and p53 Signaling in Renal Ischemia-Reperfusion Injury.

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), particularly in the settings of kidney transplantation and perioperative care. In IRI-induced AKI, ferroptosis, an iron-dependent, lipid peroxidation-driven form of regulated cell death, occurs early in proximal tubular epithelial ce...

Kazuki Ishiwata, Sawako Suzuki, Chi-Wei Lee et al. · Free Radical Biology & Medic... · 0 citations

Open access Jul 2026

Notch signaling pathway mediates anti-inflammatory effects of vagus nerve stimulation during lipopolysaccharide-induced acute kidney injury.

Using a mouse model of lipopolysaccharide (LPS)-induced AKI, it is found that CAP activation by vagus nerve stimulation (VNS) enhanced Notch2 signaling in macrophages, mitigating inflammation in the spleen and tissue damage in the kidneys, thereby protecting the kidneys.

Shuhei Kuwabara, Hiro Inoue, W. Nash et al. · Communications Biology · 0 citations