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Takahiro Yamamoto

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Open access Aug 2026

KIFC1 overexpression induces monopolar spindles by preventing centrosome separation during rapid cleavage divisions

Bipolar spindle assembly is essential for accurate chromosome segregation. KIFC1, a conserved Ran- regulated minus-end-directed kinesin-14 motor, accumulates in the nucleus during interphase and promotes chromatin-mediated spindle assembly during mitosis and meiosis. In human oocytes, reduced KIFC1 levels destabilize m...

Takahiro Yamamoto, Ai Kiyomitsu, Ming Yang et al. · 0 citations

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