Open access
Sep 2026
Evaluation of Histidine–Octamer-Modified Hyaluronic Acid as a Cytosolic Drug Delivery Material via CD44-Mediated Cellular Uptake and Endosomal Escape
His8 modification alters HA intracellular localization while preserving CD44 targeting, thereby facilitating endosomal escape and highlighting HA–His8 as a potential platform for the cytosolic delivery of macromolecular therapeutics, including proteins, peptides, and nucleic acids.
Tomona Yukimura, Hirono Ito, Takahiro Suzuki et al.
· Pharmaceutics · 0 citations