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Takahiko Fukuchi

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Open access Sep 2026

Should the Traditional Algorithm for Syphilis Screening be Abandoned? Neurosyphilis Presenting as Limbic Encephalitis: A Prozone False-Negative RPR Missed by an RPR-Only Initial Screen

Introduction Neurosyphilis is a treatable mimic of viral and autoimmune limbic encephalitis. The prozone phenomenon—antibody excess preventing the antigen–antibody lattice—can render an undiluted non-treponemal test such as the rapid plasma reagin (RPR) test falsely negative, with reactivity restored on dilution. Case...

H. Sanayama, Yuka Hayashi, Takahiko Fukuchi · 0 citations

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