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Open access Sep 2026

Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms

Abstract Schizophrenia (SCZ) and systemic lupus erythematosus (SLE) exhibit epidemiological overlap, suggesting shared genetic underpinnings. Using the largest SLE genome-wide association study (GWAS) to date, we identified a significant genetic correlation between SCZ and SLE (rg = 0.25, p = 9.0 × 10−4). Cross-trait a...

Chen Gong, N. Dand, A. W. Butler et al. · 0 citations
Open access Sep 2026

Single-cell multi-ancestry regulatory map of systemic lupus erythematosus

Integrating genomic and single-cell transcriptomic profiles from patient cohorts can uncover regulatory effects underlying genetic associations with disease. Here we present SLEmap, a multi-ancestry single-cell expression quantitative trait locus (sc-eQTL) map generated from peripheral blood mononuclear cells from 281...

Haerin Jang, C. Sutherland, Wanseon Lee et al. · 0 citations

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