Anagrelide remodels the PDE3A-SLFN12 interactome to associate with translation initiation machinery in cancer cell lines.
In this proposed model, anagrelide remodels the interactome of the PDE3A-SLFN12 complex, which relocalizes and accumulates near the mRNA entry channel of the 43S pre-initiation complex, which provides important mechanistic context for how PDE3A modulators act within the cell.
S. Salmikangas, Iina Lindholm, Nasrin Sultana et al.
· Molecular & Cellular Proteom... · 0 citations