Author

Tom van der Valk

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Open access Oct 2026

G-ALN: a GPU-accelerated BWA-aln algorithm for palaeogenomics

Summary The most commonly used method to achieve optimal mapping for short and damaged ancient DNA (aDNA) reads is the BWA-aln algorithm with seeding disabled. However, this CPU-based algorithm is computationally demanding, as the aligner must tolerate mismatches and indels across the entire read. To improve alignment...

Bilal Sharif, Krister Hedfors, T. van der Valk et al. · bioRxiv · 1 citation

Open access Aug 2026

A multiplex genome editing pipeline for rapid combinatorial trait engineering.

A multiplex genome engineering pipeline capable of introducing up to eleven genomic modifications across seven different genes simultaneously in viable founder mice is established, advancing methods of rapid establishment of complex genetic models, with a wide array of applications.

Rui Chen, M. Coquelin, Kanokwan Srirattana et al. · Cell Reports Methods · 0 citations