Marine brown algae are an important source of bioactive metabolites with promising anticancer potential. Scytosiphon lomentaria has repeatedly shown selective antitumor activity, although the active metabolite associated with its lipophilic fractions had not previously been identified. Here, five solvent extracts were...
Matteo Mauceri, Abdul-salam Juhmani, R. Zangrando et al.· Marine Drugs· 0 citations
The discovery of a novel N-hydroxyindole-2-carboxamide class of PDIA3 inhibitors, exemplified by compound AV22 (1o), which effectively inhibits PDIA3 activity and exerts broad-spectrum antiviral activity against major human respiratory viruses.
G. Bononi, G. Sibille, Erika Plicanti et al.· Journal of Medicinal Chemist...· 0 citations
The development of LogPpred, an AI-based predictor of molecular lipophilicity, a robust, accurate, and transparent tool for the early assessment of molecular lipophilicity in medicinal chemistry and drug discovery is reported.
Lisa Piazza, Lara Sortino, Alessio Costa et al.· Molecules· 0 citations
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