T. T. Nguyen

Proteomic Signatures in Neuronal and Glial Cell Models of Niemann-Pick Disease Type C

Niemann-Pick disease type C (NPC) is a lysosomal storage disorder characterized by the accumulation of unesterified cholesterol and glycosphingolipids in the late endosomal/lysosomal system, resulting in region-specific neurodegeneration. While the mechanism through which defective NPC1 protein and thus altered chole...