Optimizing Regularized Logistic Regression Pipelines on Cleaned Biomarker Datasets: A Leakage-Proof Benchmarking Protocol for Diagnostic and Prognostic Modeling
Logistic regression remains the workhorse of biomarker-based diagnostic and prognostic modeling, and for principled reasons: it yields calibrated probabilities when fitted and validated correctly, its coefficients support biological and clinical interpretation, and its statistical behavior under limited events is thoro...