The apolipoprotein E ε4 allele (APOE4) is the main genetic risk factor for incidence and earlier onset of dementia, and APOE4 carriers are thus considered a key target group for dementia risk reduction. APOE4 carriership also impacts the association between lifestyle and cognitive decline. Our meta-analysis inves...
J. Lehtisalo, Ari Solomon, E. Levälahti et al.· Communications Medicine· 0 citations
The findings suggest that BBMs, potentially in combination with genetic information, may help identify individuals with a more progressive AD‐related biological profile who may derive greater benefit from multidomain intervention.
Tetsuaki Kimura, A. Nakamura, T. Sugimoto et al.· Alzheimer's & Dementia· 0 citations
Background Although a lower body mass index (BMI) has been identified as a prognostic risk factor among older adults with cognitive impairment, it remains unclear which body composition are associated with prognosis. Objective This study investigated the relationship between body composition and mortality in older adul...
K. Uchida, T. Sugimoto, Takeshi Nakagawa et al.· Journal of Alzheimer's Disea...· 0 citations
Among adults aged ≥75 years with type 2 diabetes, SGLT2i initiation was associated with lower all-cause mortality and renal risk compared with DPP-4i initiation, and the higher observed stroke risk requires cautious interpretation.
H. Noma, Atsushi Goto, T. Sugimoto et al.· Age and Ageing· 1 citation
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