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Author

T. Strünker

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Open access Aug 2026

Off-Target Activation of CatSper Limits the Utility of a Novel Small Molecule Slo3 Inhibitor and its Derivatives in Human Sperm

The sperm-specific K+ channel Slo3 is required for sperm function and fertilization in mice and humans. Due to the lack of selective pharmacological tools, its molecular and cellular physiology in human sperm has remained only ill-defined, though. The compound VU0546110 (1) was recently introduced as the first selectiv...

Teresa Mittermair, Jens Münchow, T. Strünker et al. · 0 citations

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