Author

T. Stervinou

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Open access Sep 2026

Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart

Abstract Increased late sodium current (INaL) is a central mechanism underlying both inherited and acquired cardiac arrhythmias. Although Nav1.5 is the dominant cardiac sodium channel, multiple tetrodotoxin-sensitive (TTX-S) Nav isoforms are also expressed in cardiomyocytes, particularly within transverse tubules, wher...

Hugo Millet, M. Choteau-Bodor, T. Stervinou et al. · Europace · 0 citations

Open access Aug 2026

Desmin p.R406W mutation is associated with arrhythmias through structural and electrophysiological remodeling

This study highlights the effectiveness of hiPSC-CMs and EHTs in recapitulating the clinical phenotype of desminopathy, providing a platform for investigating the mechanisms of early-onset cardiac arrhythmias and SCD.

M. Geryk, T. Stervinou, Martin Bouaud et al. · bioRxiv · 0 citations

Open access Jul 2026

Developmental mis-specification of cardiac conduction and structure transcriptome in Brugada syndrome

The findings support a model in which non-SCN5A BrS is associated with early dysregulation of developmental transcriptional networks controlling cardiac conduction and extracellular matrix organization, whereas SCN5A-mediated BrS primarily results from sodium channel deficiency with limited developmental remodeling.

T. Stervinou, B. Cimarosti, R. Canac et al. · medRxiv · 0 citations