Author

T. Spires-Jones

3 papers indexed here

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Open access Oct 2026

Mapping polygenic risk scores to brain cells: insights for neurodegenerative diseases

Neurodegenerative diseases (NDDs) are driven by multiple related yet distinct pathological processes that evolve over decades, resulting in substantial clinical and neuropathological heterogeneity. Postmortem examinations of older individuals frequently reveal multiple coexisting neuropathologies, however, the underlyi...

E. Simmonds, A. Mckeever, U. Yaman et al. · medRxiv · 0 citations

Open access Aug 2026

Oligodendrocyte dysfunction in human age-related cognitive decline.

Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain's myelin-forming cells-oligodendrocytes-in explaining this variance. By investigating neuropathol...

Georgina A. Craig, Emeric Merour, L. Seeker et al. · Nature Medicine · 0 citations

Open access Aug 2026

Breakdown in the synaptic vesicle cycle defines early and reversible cortical pathogenesis in ALS

Synaptic failure is considered an early driver of Amyotrophic Lateral Sclerosis (ALS), yet identifying the molecular events initiating synaptic decline remains challenging in end-stage human tissue. Here, we exploit the late involvement of the primary visual cortex (Brodmann Area 17 (BA17)) to investigate early disease...

Zsófia I. László, Anna Sanchez-Avila, Anna McFarlane et al. · bioRxiv · 0 citations