Review
Open access
Aug 2026
Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification
The Parkinson’s Vulnerability Index (PVI) is proposed, a hypothesis-generating multidimensional model combining genetic, enzymatic, alpha-synuclein seeding, cognitive, olfactory, and neuroimaging biomarkers to facilitate biological stratification and improve the design of mechanism-targeted clinical trials.
Livia Livinț-Popa, Andreea Nicolaie, A. Maștaleru et al.
· Medical Science · 0 citations