Association between up-titration of guideline-directed medical therapy and clinical outcomes in patients with chronic heart failure with reduced ejection fraction
The optimisation of guideline-directed medical therapy (GDMT) is associated with favourable clinical outcomes in heart failure (HF), particularly in HFrEF. The GDMT score has been proposed to quantify GDMT optimisation. However, it remains unclear whether an increase in the GDMT score is associated with clinical...