Open access
Aug 2026
Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers
Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic flux and lactate product...
Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al.
· Nature Communications · 1 citation