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Author

T. Paranhos

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Review Open access Oct 2026

Is Klotho associated with cognitive and motor decline in Parkinson’s disease? A systematic review and meta-analysis

Background: Klotho is an anti-aging protein with demonstrated neuroprotective properties in preclinical models of Parkinson's disease (PD). However, the relationship between Klotho levels and clinical outcomes in human PD remains unclear. Objective: To examine associations between Klotho levels and cognitive/motor func...

L. Fontenele, Petrone Bandeira dos Santos, T. Paranhos et al. · 0 citations
Open access Aug 2026

EOAD-Signature Atrophy Predicts Dementia in Early-Onset MCI due to Alzheimer Disease

Findings support the potential value of EOAD-signature atrophy as an MRI-based biomarker for individualized prognostication and clinical trial stratification and support the potential value of EOAD-signature atrophy as an MRI-based biomarker for individualized prognostication and clinical trial stratification.

T. Paranhos, Yuta Katsumi, M. Brickhouse et al. · 0 citations
Aug 2026

Non-invasive brain stimulation increases default mode network functional connectivity in a patient with Posterior Cortical Atrophy

This case report supports further controlled clinical trials using functional connectivity guided rTMS in PCA and supports the hypothesis that intermittent theta burst, a form of rTMS, can modulate functional networks and improve associative memory in a patient with PCA presenting with memory impairments.

T. Paranhos, Anna Du, Ryan Eckbo et al. · 1 citation

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