Variants conferring a high mRNA ER localization score consistently enhanced protein secretion, confirming the mechanistic relationship between mRNA targeting to the ER and secretion efficiency and the correlation between variant performances across both reporters suggests a shared regulatory mechanism.
Gal Haimovich, Gabriela Lobinsky, Shu-Ting You et al.· bioRxiv· 0 citations
Messenger RNA (mRNA) localization to specific subcellular regions is crucial for proper protein translation and localization. Potential means to localize mRNAs include cis-acting or structural motifs embedded within the sequence. We previously identified a secretion-enhancing cis regulatory targeting element (SECReTE)...
Gal Haimovich, Gabriela Lobinsky, Shu-Ting You et al.· bioRxiv· 0 citations
Using human brain organoids and mouse models, it is shown that loss of NDE1, a gene closely associated with microcephaly, disrupts progenitor identity, prolongs mitosis, and alters regional patterning in the forebrain.
R. Y. Tshuva, Jeyoon Bok, Mio Nonaka et al.· Nature Communications· 0 citations
It is shown that RTTN has an unrecognized function at the core of the translation machinery and is enriched in cycling first-trimester neural progenitors and physically associates with ribosome-biogenesis and RNA-processing factors.
A. Hadar, K. Draganova, V. Iyer et al.· bioRxiv· 0 citations
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