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CLINICAL TRIAL REGISTRATION jRCT2031230456 (https://jrct.mhlw.go.jp/latest-detail/jRCT2031230456).
Systemic therapy for biliary tract cancer (BTC) has evolved substantially over the past two decades. Gemcitabine plus cisplatin was established as the global standard first-line regimen, followed by further optimization through alternative doublets, intensified triplet chemotherapy, and the recent introduction of immun...
Neuroendocrine carcinoma (NEC) of the biliary tract is an exceptionally rare and highly aggressive malignancy, and its molecular subtype landscape and diagnostic boundaries remain poorly defined. We retrospectively analyzed 42 biliary tract NECs, including 22 surgically resected cases, arising in the intrahepatic bile...
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