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T. Nguyen

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Open access Jul 2026

Genomic atlas of cardiac and adiposity imaging phenotypes

A whole-genome sequencing-based atlas of 42 IDPs in UK Biobank, comprising 11 cardiac MRI traits in up to 75,562 participants and 31 DXA-derived adiposity traits in up to 66,194 participants highlights cardiac and adiposity IDPs as complementary genetic endophenotypes for dissecting cardiometabolic disease.

H.-M. Tsao, L. Smith, A. Richard et al. · 0 citations
Open access Jul 2026

ASXL3 truncating patient variants mediate transcriptional gain-of-function and are antisense oligonucleotide-responsive

ASXL3 patient truncations in neurodevelopmental condition Bainbridge-Ropers syndrome are shown to mediates gain-of-function (GOF) by escaping nonsense-mediated decay and Cullin 4-dependent degradation, resulting in aberrant protein accumulation, widespread transcriptional dysregulation, and altered chromatin accessibil...

Y. Nakamura, T. Nguyen, N. Mor et al. · 0 citations

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