Sep 2026
Design, synthesis, molecular docking, ADMET and anticancer evaluation of novel pyridine/thiazole hybrids as dual VEGFR-2 and EGFR kinase inhibitors.
The synthesis of a number of novel pyridine/thiazole hybrids 1 to 6a,b and their screening as possible anticancer drugs through dual targeting of VEGFR-2 and EGFR are highlighted and every synthesized compound demonstrated minimal toxicity toward VERO normal cells.
N. Ahmed, Rizk E. Khidre, Mohamed R. Khidre et al.
· Bioorganic chemistry (Print) · 0 citations