T. Nakagaki

Optimization of a thermal shaker-aided quaking-induced conversion platform for the rapid detection of prion seeding activity in human samples

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder caused by the misfolding of the normal prion protein (PrPC) into its pathogenic form (PrPSc). Therefore, effective clinical management and infection control require diagnostic assays that combine sub-attomole sensitivity with a t...