Patient‐derived organoids (PDOs) have emerged as an effective experimental platform for bridging the long‐standing gap between traditional in vitro cancer models and the biological complexity of actual tumors. These three‐dimensional cultures (3D), derived directly from patient tissues, preserve essential architectural...
Abdullah Jabri, Mohamed Alsharif, Abdulaziz Mhannayeh et al.· Cell Biochemistry and Functi...· 0 citations
One of the major contributors to persistent healthcare and community-associated infections is S. aureus, which has a remarkable ability to form biofilms that protect it against the host immune system and antimicrobial therapy. In recent years, it has become clear that biofilm development is a highly orchestrated and dy...
M. Azhar, T. Mir, Sana Ahmed et al.· Frontiers in Microbiology· 0 citations
A modular aptamer-guided LNP platform to enable hepatocyte-selective genome editing through an LDLR-independent route is designed and validated and a validated LDLR-null hepatocyte model is validated for studying LDLR-dependent biology and disease.