T. Lehtimäki

Polygenic risk for schizophrenia predicting age-specific fluctuations in depressive symptoms: Findings from the Young Finns Study.

Depressive symptoms in adolescence may represent intermediary phenotypes or transdiagnostic susceptibilities related to high polygenic risk for schizophrenia (PRSscz), which appears to explain age-specific fluctuations in depressive symptoms.

Lipoprotein(a): Particle vs mass and prevalent cardiovascular disease in the cardiovascular risk in Young Finns study population.

BACKGROUND Lipoprotein(a) [Lp(a)] can be reported as mass (mg/dL) or particle concentration (nmol/L). Because Lp(a) acts at the particle level, molar concentration may better reflect biologically relevant exposure. OBJECTIVE To compare molar- and mass-based Lp(a) in relation to cardiovascular outcomes, risk classific...

Robust inference and correlates from genetic associations with personality

Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...

Analysis of Genetic Risk Scores, Exercise Testing Data and Clinical Data for Prediction of Sudden Cardiac Death in the Fincavas Cohort

Ultrasound-detected fatty liver in young adults and long-term risk of atherosclerotic cardiovascular disease: The Young Finns Study.

BACKGROUND Fatty liver is the most common chronic liver disease globally and is associated with increased cardiovascular risk. Evidence specifically addressing fatty liver and cardiovascular outcomes in young adults from European population-based cohorts remains scarce. METHODS Fatty liver was assessed by abdominal u...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood factors and polygenic risk scores (PRSs). Data fro...

Associations of lipoprotein(a) with fasting insulin, fasting glucose, and incident type 2 diabetes: a prospective analysis from the Young Finns Study

Inverse associations between Lp(a) and fasting glucose were observed in males and higher adult Lp(a) concentrations were prospectively associated with lower risk of incident type 2 diabetes, in the prospective Young Finns Study cohort.

Adolescent weight gain trajectories and their associations with biological aging: a genetically informed study.

Higher level of adolescent BMI partly mediated the association between higher BMI-PRS and accelerated biological aging from late adolescence to middle adulthood, indicating that high BMI in adolescence may accelerate biological aging.