Author

T. Latiano

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Open access Sep 2026

Circulating tumor DNA tumor fraction as a biomarker in refractory metastatic colorectal cancer: findings from the CAVE-2 GOIM trial

Liquid biopsy guided anti-EGFR rechallenge therapy is gaining ground as a potential option for patient with refractory metastatic colorectal cancer. However, the identification of potential biomarkers to implement patient's stratification is required. The CAVE-2 GOIM trial investigated the role of rechallenge with cetu...

Davide Ciardiello, G. Martini, Luca Boscolo Bielo et al. · The journal of liquid biopsy · 0 citations

Open access Aug 2026

Predictive biomarkers for cetuximab-based rechallenge therapy in metastatic colorectal cancer: a pooled analysis of the CAVE and CAVE-2 GOIM studies

In cetuximab–avelumab therapy, the absence of liver metastases and longer anti-EGFR-free interval might represent potential biomarkers and single-agent cetuximab activity is not influenced by clinical factors.

D. Ciardiello, G. Martini, F. Pietrantonio et al. · ESMO gastrointestinal oncolo... · 0 citations

Open access Jul 2026

Rare AFG3L2 and POLG Variants Suggest a Role for Mitochondrial Dysfunction in Enteric Neuronal Vulnerability in Idiopathic Achalasia

Findings support a potential link between mitochondrial dysfunction, enteric neurodegeneration, and idiopathic achalasia and rare mitochondrial-related variants may contribute to disease susceptibility in selected individuals by increasing vulnerability of inhibitory enteric neurons, although functional validation and...

A. Latiano, F. Tavano, L. Micale et al. · International Journal of Mol... · 0 citations