Open access
Aug 2026
Circulating Microbial DNA as a Potential Cancer Biomarker: Technical Challenges and Controlled Evaluation
Much of the apparent cmDNA structure, including its agreement with a published cancer-microbiome catalog, is explained by base composition and reference-database architecture rather than authentic biology, and short-read k-mer pipelines cannot separate the two on their own.
Daisy Fry Brumit, Daniel Bsteh, Shan Sun et al.
· bioRxiv · 0 citations