Abstract INTRODUCTION Elevated cerebrospinal fluid (CSF) inflammatory proteins have been reported in Alzheimer's disease (AD), yet whether they reflect peripheral immune cell infiltration or central nervous system (CNS)–intrinsic pathological processes remains unclear. We tested whether AD exhibits a distinct CSF prote...
Sina Zaic, T. König, O. Keritam et al.· Alzheimer's & Dementia· 0 citations
Background and objectives Myasthenia gravis associated with antibodies against muscle-specific kinase (MuSK-MG) is a well-characterized IgG4-autoimmune disease, however, the mechanisms driving IgG4 predominance remain poorly understood. This study investigated whether promoter DNA methylation of cytokine genes involved...
Cansu Elmas, A. Stoccoro, Martina Lari et al.· bioRxiv· 0 citations
In this study, we designed a gene panel based on Nanopore long-read sequencing using adaptive sampling, targeting n = 564 genes associated with Parkinson’s disease (PD) and repeat expansion disorders. We investigated its diagnostic utility in n = 18 patients with (1) pathogenic variants in LRRK2, PRKN, SNCA, and RAB32...
A. Fienemann, J. C. Prietzsche, Joshua Laβ et al.· npj Parkinson's Disease· 0 citations
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