BACKGROUND
Epilepsy is a relevant comorbidity of dementia due to Alzheimer's Disease (AD) and probably directly related to its pathology. We aimed to generate hypotheses how interictal epileptiform discharges (IEDs) may be associated with pathological levels of AD markers from cerebrospinal fluid (CSF).
OBJECTIVE
To...
Livia Rabea Ott, W. Hermann, Rüdiger Köhling et al.· Epilepsy Research· 0 citations
These findings provide indirect evidence that the presynaptic Kv7 channel function may be at least partially intact in the epileptic CA1, and may be speculated whether potassium channel activators could pose a risk to enhance rather than depress short-term plasticity at Schaffer collateral–CA1 synapses in epilepsy.
Emma Schnell, Steffen Müller, Rüdiger Köhling et al.· Brain Science· 0 citations
Introduction The non-inactivating potassium channels Kv7.2 and Kv7.3 contribute to the neuronal resting membrane potential and regulate neuronal excitability. Previous studies have indicated a transcriptional downregulation of these channels in temporal lobe epilepsy, both in patients and in the pilocarpine-induced ani...
E. Nissen, T. Kirschstein, Astrid Bertsche et al.· Frontiers in Neurology· 1 citation
The findings indicate that the APPswe/PS1dE9 mouse model does not exhibit evidence of major integrative brain clearance impairment, despite this being a hallmark of sporadic AD in humans and suggest limitations of this model for studying clearance-related mechanisms of late-onset AD should be acknowledged when planning...
L. Müller, Charlotte Köhler, T. Lindner et al.· Fluids and Barriers of the C...· 0 citations
Aims To explore the mechanisms involved in esophageal body longitudinal muscle contraction induced by electrical field stimulation. Methods Isometric contractions of esophageal segments from wistar rats in an organ bath were induced by electrical field stimulation (duration 1 s, frequency 1-100 Hz, intensity 30-90 V) b...
Michelle Gräfe, Julius-Neven Kriese, T. Kirschstein et al.· Frontiers in Physiology· 0 citations
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