Importance
Early identification of patients at high risk of relapse is key to personalized preventive strategies in major depressive disorder (MDD). However, current predictive models do not adequately account for the multimodal factors contributing to MDD relapse and fail to provide clinically meaningful predictions....
L. Teutenberg, N. Winter, P. Usemann et al.· JAMA psychiatry· 0 citations
Symptoms and psychosocial factors interact dynamically across affective and psychotic disorders, yet longitudinal evidence remains limited. Building on the network theory of psychopathology, this study conceptualizes mental disorders as systems shaped by symptom-environment interactions. Using data from a two-site Germ...
Rui Tan, F. Stein, L. Teutenberg et al.· European Archives of Psychia...· 0 citations
Biofluid proteins are promising transdiagnostic markers for delineating disease heterogeneity in psychosis. This study examined proteomic profiles in a transdiagnostic early psychosis sample to test the hypothesis that psychosis is associated with proteomic signatures of premature aging. We analyzed proteomic data from...
J. Seitz-Holland, M. Haaf, A. Mendes-Silva et al.· Brain, behavior, and immunit...· 0 citations
Depressive symptoms show an increased prevalence in individuals affected by spinal cord injury (SCI), yet their in-depth characterization and association with clinical outcomes remain underexplored. We investigated depressive symptoms, operationalized through the items in the Beck Depression Inventory (BDI), in a longi...
Roman Schefzik, L. Heutehaus, C. Schuld et al.· Scientific Reports· 0 citations
BACKGROUND
Negative expectations towards the future are frequently observed in patients with major depressive disorder (MDD) and linked to less favourable outcomes like worse treatment response and suicidal behaviours. Despite clinical significance, the neurobiological underpinnings of negative expectations remain larg...
Laila Noor, F. Stein, K. Brosch et al.· Journal of Affective Disorde...· 0 citations
BACKGROUND
Formal thought disorder (FTD) is a key determinant of social functioning in schizophrenia. However, existing syntheses have not differentiated positive versus negative FTD dimensions, which have distinct trajectories, mechanisms, and treatment implications. We examined the differential associations of positi...
Clara Benedetta Caterina Soldovieri, D. Elleuch, Jessica Ahrens et al.· Schizophrenia Research· 0 citations
It is suggested that cumulative illness burden is a key factor associated with brain structural decline in MDD, while also suggesting potential reversibility in more favorable disease courses.
A. Kraus, J. Goltermann, T. Borgers et al.· JAMA Network Open· 0 citations
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
M. Gruber, Henrike Renaud, M. Mauritz et al.· Psychotherapy and Psychosoma...· 0 citations
Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...
M. Konowski, A. Kraus, J. Goltermann et al.· medRxiv· 0 citations
This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.
L. Fehse, A. H. Ribeiro, N. Winter et al.· Gut microbes· 0 citations
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