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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

T. Kato

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Open access Sep 2026

499. Chronic stress impairs synaptic central metabolism in the prefrontal cortex, driving depression-related behaviors in mice

It is demonstrated that chronic stress disrupts central energy metabolism at prefrontal cortical synapses, driving to synaptic pathology and behavioral vulnerability and highlighting synaptic metabolic pathways as promising pharmacological targets for the treatment of stress-related psychiatric disorders.

H. Nagai, K. Ota, C. Numa et al. · 0 citations

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