Innate immunity provides a critical first line of defense against pathogens and homeostatic perturbations. Pattern recognition receptors detect these disruptions and initiate immune responses through multi-protein complex formation to drive inflammatory signaling and cell death pathways. Key cytosolic complexes formed...
Saurabh Upadhyay, R. Nagampalli, S. Resende et al.· Cell Research· 2 citations
Type I IFNs are suggested as a potential therapeutic strategy for NLRP1-driven inflammatory diseases by identifying a TLR4–TRIF–IRF3 signaling axis that induces type I IFNs to negatively regulate NLRP1 transcription, thereby blocking NLRP1-driven, caspase-1/caspase-8/RIPK3–dependent PANoptosis.
B. Sharma, Harisankeerth Mummareddy, S. Chadchan et al.· EMBO Reports· 1 citation
Severe infections often cause life-threatening inflammation, multi-organ failure, and death. During infection, pathogens carry multiple pathogen-associated molecular patterns (PAMPs) such as LPS, flagellin, nucleic acids, and lipoproteins which activate more than one pattern-recognition receptor (PRR). These PRRs...
Balamurugan Sundaram, T. Kanneganti· Journal of Immunology· 0 citations
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