Author

T. Kaisho

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Open access Sep 2026

Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewed intestinal inflammation.

DNA ligase IV (LIG4) is essential for DNA double-strand break (DSB) repair. Hypomorphic LIG4 variants cause LIG4 syndrome, characterized by growth disturbance, increased radiosensitivity, predisposition to malignancies, adaptive immunodeficiency and inflammatory conditions. Most of these manifestations are recapitulate...

Yusuke Yamashita, Hideki Kosako, Takashi Kato et al. · JCI Insight · 0 citations

Open access Aug 2026

46 Anti-tumour immune responses in melanoma brain metastases require cDC1 population and the extracranial tumour

Brain metastases (BrM) are associated with poor prognosis, partially due to the specialized immune-microenvironment in the brain. Our previous study demonstrated that intracranial tumours alone are poorly immunogenic, but simultaneous presence of a subcutaneous tumour, mimicking the extracranial disease observed...

Dario Guglietta, Alca Revalova, Fiona R. James et al. · Neuro-Oncology · 0 citations