Open access
Jul 2026
IL-26-driven epigenetic remodeling promotes immune evasion in colorectal cancer
Cancer cells acquire malignant traits through epigenetic remodeling driven by inflammatory secretomes in the tumor microenvironment. However, how immune-derived inflammatory factors regulate cancer cell epigenetics remains poorly understood. Here, we show that IL-26 produced by tumor-specific type 17 T cells acts as a...
T. Itoh, R. Hatano, Y. Hasegawa et al.
· Nature Communications · 0 citations