Streptococcus pneumoniae (pneumococcus) represents a key clinical challenge, being a major global cause of morbidity and mortality. Typically existing as a nasopharyngeal commensal, pneumococcus undergoes significant metabolic changes during its switch to a virulent pathogen, when it can cause severe pneumoniae, bacter...
Nicholas S. Briggs, S. Camaione, J. Goodall et al.· Microorganisms· 0 citations
Culture-based methods remain standard practice for pathogenic bacterial detection in routine diagnostic laboratories but frequently fail to identify pathogens, particularly in low bacterial burden or antibiotic-exposed samples. While full-length 16S rRNA sequencing improves detection and taxonomic resolution, its adopt...
Tom Saville, Magdalena Dąbrowska, Pei-Jun Zhang et al.· Journal of Infection· 0 citations
Respiratory syncytial virus (RSV) causes over 100,000 annual deaths, predominantly in low- and middle-income countries, yet immunological correlates of protection remain poorly defined in high-burden settings. This study aims to identify immunological correlates of protection against RSV infection, and to compare the r...
David Hodgson, S. Jarju, L. Gatcombe et al.· Nature Communications· 0 citations
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