T. Hyde

Multi-omic spatial mapping of the human habenula defines the molecular and anatomical organization of medial and lateral subregions

The habenula (Hb) is a small epithalamic midline structure critical for reward processing and mood regulation that is implicated in many complex brain disorders, including depression and addiction. The molecular anatomy of the Hb has been well-characterized in model organisms, but little is known about its organization...

Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability

Association Between Age-Dependent DNA Methylation Changes at FKBP5 Enhancer Sites and Increased Cortical Gene Expression in Schizophrenia.

Evidence supports the association of aging and psychiatric diagnosis with changes in FKBP5 DNAm in functionally relevant regulatory elements of the human frontal cortex.

Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

A spatial transcriptomic atlas of the human amygdala from nine neurotypical donors provides a foundational resource and framework for accelerating cross-species comparisons and human disease-focused investigations.

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia

A refined approach to define dynamic gene relationships is proposed, able to identify aberrant neuron-oligodendroglia interactions when applied to the study of schizophrenia.