The accumulation of α-synuclein (α-syn) in the form of Lewy bodies and Lewy neurites is a neuropathological hallmark of Parkinson’s disease (PD) and is closely associated with disease progression. Targeting the autophagy pathway to enhance the clearance of α-syn aggregates therefore represents a promising therapeutic...
M. Kitagawa, Kengo Miyamoto, Kozo Yoshida et al.· Frontiers in Neurology· 0 citations
ABSTRACT INTRODUCTION Anti-Yo antibody–associated paraneoplastic neurological syndrome (PNS) is a rare immune-mediated disorder that often presents with subacute cerebellar symptoms and is frequently associated with breast and gynecological malignancies. CASE PRESENTATION A woman in her 50s developed subacute progressi...
Moe Tasaki, Misato Okazaki, Y. Horimoto et al.· Surgery Case Reports· 0 citations
Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is an early-stage synucleinopathy characterized by brainstem pathology. In rodents, the pontine tegmentum contains a REM sleep centre, the sublaterodorsal nucleus, which expresses corticotropin-releasing hormone binding protein (CRHBP). While the invol...
Masakazu Hirose, Kenji Yoshinaga, Yoshifumi Mori et al.· Brain Communications· 0 citations
Myelin oligodendrocyte glycoprotein antibody‐associated disease can occur in older adults, but onset in nonagenarians is uncommon. In this age group, acute or subacute visual loss often requires differentiation from ischemic, diabetic retinal, and glaucomatous disorders.
A 91‐year‐old woman presented with...
Isamu Takai, Yuji Tomizawa, Y. Hoshino et al.· Clinical and Experimental Ne...· 0 citations
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