Open access
Aug 2026
Incorporation of native HCV E1E2 into a nanoparticle vaccine platform
Liudmila Kulakova, Sarah Jeong, Dong-Xiu Zhang et al.
· bioRxiv · 0 citations
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Open access
Aug 2026
The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages.
Describing the genetic, structural, functional, and epitope features of 25 BD-directed nAbs isolated from HCV-infected individuals or immunized macaques underscores BD as a promising target for rational HCV vaccine design.
Fang Chen, Yen Thi Kim Nguyen, Yi-Zong Lee et al.
· Cell Reports · 0 citations
Open access
Jul 2026
Induction of Robust Immunity Against Hepatitis C Virus Using Rationally Adjuvanted Microneedle Patches Integrating A Secreted Form of E1E2 Heterodimer 2259568
The preclinical development of a novel HCV vaccine candidate engineered by formulating a novel native-like secreted E1E2 immunogen and a well-established combinatorial adjuvant of QS-21 + 3D-(6-acyl) PHAD into unique microneedle patches (MNPs).
Yi-Nuo Zhang, A. Dhayani, Stephen C. Balmert et al.
· Journal of Immunology · 0 citations