Author

T. Elgun

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Open access Sep 2026

Midazolam Reduces Metabolic Viability and Induces Apoptosis in MIA PaCa-2 Pancreatic Cancer Cells with Selective Transcriptional Modulation of Wnt and Hedgehog Components: A Preliminary In Vitro Study

Background. Pancreatic ductal adenocarcinoma remains difficult to treat and has an exceptionally poor prognosis. While prior studies have noted antitumour properties for midazolam in pancreatic cancer, whether this response involves developmental signaling pathways is unclear. Here, we evaluated midazolam-treated MIA P...

Irmak Fatoş Korkmaz, T. Elgun, Ç. Aktaş et al. · Pharmaceuticals · 0 citations

Open access Sep 2026

Melatonin Differentially Modulates Temozolomide Responses in Glioblastoma and Endothelial Cells: Associations with Global DNA Methylation and Cortistatin Levels

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains highly resistant to current therapeutic strategies. Temozolomide (TMZ) is a standard chemotherapeutic agent used in GBM treatment; however, intrinsic and acquired resistance limits its efficacy. This study investigated treatment-associa...

G. Gundogan, A. Yurttaş, Y. Oltulu et al. · Current Issues in Molecular... · 0 citations

Open access Jul 2026

Age-Adjusted Associations Between Routine Systemic Inflammatory Markers and Anti-Müllerian Hormone in Reproductive-Age Women: A Retrospective Cross-Sectional Study

Background: Anti-Müllerian hormone (AMH) is widely used as a marker of ovarian reserve and is strongly influenced by chronological age. Although inflammation has been implicated in ovarian aging and follicular dysfunction, whether routinely measured peripheral inflammatory markers provide additional information regardi...

Mete Hakan Karalök, Bağnu Dündar, Ayhan Parmaksiz et al. · Biomedicines · 0 citations