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Author

T. D'Aoust

2 papers indexed here

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Open access Sep 2026

Multi-trait Polygenic Profiling and Survival Free of Dementia and Disability: Results from the Health and Retirement Study

ABSTRACT Objective: To determine whether a multi-trait polygenic profile for dementia is associated with dementia- and disability-free survival in middle-aged and older adults. Background: Clinical trials of brain health and aging increasingly use holistic, patient-centered outcomes that capture overall health status....

Y. Tawaldemedhen, S. Clocchiatti-Tuozzo, C. Rivier et al. · 0 citations
Open access Sep 2026

Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease

A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.

T. D'Aoust, A. Tsuchida, C. Dufouil et al. · 0 citations

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