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Author

T. Cova-Guzmán

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Open access Oct 2026

Clinical manifestations of patients with STAT1 gain-of-function variants in Mexico

Germline Signal Transducer and Activator of Transcription 1 (STAT1) gain-of-function (GOF) variants enhance cellular responses to IL-27 and type I, II, and III interferons, predisposing to fungal, bacterial, and viral infections and immune dysregulation. Mexican patients with pathogenic STAT1-GOF variants id...

T. Cova-Guzmán, Satoshi Okada, M. Tsumura et al. · 0 citations

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