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Open access Oct 2026

Childhood maltreatment and the developing brain: toward individualized models of psychiatric risk.

Childhood maltreatment shapes brain development in ways that vary by adversity type, developmental timing, and genetic vulnerability to psychiatric illness-a heterogeneity that conventional approaches capture poorly. We contend that normative modeling, multivariate methods, and polygenic risk scores offer complementary...

Haley R. Wang, C. Bearden, T. C. Ho · 0 citations
Review Sep 2026

Permeability of the intestinal epithelial and blood-brain barriers as therapeutic targets in inflammatory depression.

Inflammation has emerged as a compelling causal contributor to depression, serving both as a biological pathway underlying specific depressive symptoms (notably anhedonia, fatigue, and cognitive difficulties) and as a defining feature in a subtype of this disorder characterized by elevated levels of circulating cytokin...

T. C. Ho, G. A. Vignolle, Danny J. J. Wang et al. · 0 citations

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