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Author

T. Betthauser

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Oct 2026

EXPRESS: Synaptic density PET mediates the relationship between Alzheimer's disease pathology and cognitive performance.

INTRODUCTION Synaptic loss is one of the strongest post-mortem predictors of Alzheimer's disease (AD) severity and may impact how pathology affects cognition. This study compared regional [11C]UCB-J synaptic density across the AD continuum and evaluated the extent to which synaptic density mediates relationships betwee...

Max J. McLachlan, Brecca Bettcher, Rebecca E. Langhough et al. · 0 citations
Open access Jul 2026

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.

Higher plasma p-tau217 levels were consistently associated with increased risk of clinical progression and accelerated cognitive decline, and support the potential of p-tau217 for prognostic model development, with direct implications for future trial design.

R. Buckley, D. Townsend, C. Birkenbihl et al. · 3 citations
Open access Aug 2026

Region-specific cerebral blood flow differentiates cognitively impaired and unimpaired individuals with core Alzheimer's disease pathology

MRI measures of cerebral blood flow and white matter hyperintensities differentiated NDAN from AD+MCI, highlighting vascular contributions to cognitive resilience, and CBF differentiated AD+MCI from Controls.

S. Fernandes‐Taylor, I. Driscoll, M. Glittenberg et al. · 0 citations
Open access Jul 2026

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).

G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al. · 5 citations

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