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Author

T. Aparicio

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Open access Sep 2026

Accelerated Adaptive Evolution of Gram‐Negative Bacteria With a Broad‐Host‐Range Dual Base Editor

ABSTRACT Adaptive laboratory evolution (ALE) is a powerful strategy for exploring functional solution spaces, yet its pace is fundamentally constrained by low spontaneous mutation rates. Here, we present a broadly applicable genetic device that accelerates genome diversification in Gram‐negative bacteria through the tr...

T. Aparicio, Gabriele Capriglia, F. Mapelli et al. · 0 citations
Open access Jul 2026

Comparative analysis of precursor supply and pathway reinforcement strategies for shikimic acid biosynthesis in Pseudomonas putida

The shikimate pathway is a central metabolic route for the biosynthesis of high-value aromatic compounds. Traditional metabolic engineering strategies have largely focused on overexpressing pathway-specific genes, enhancing precursor supply, or introducing feedback-resistant variants of 3-deoxy-D-arabino-heptuloson...

İrem İlter, Tanya Beril Korkmaz, Hatice Arslan et al. · 0 citations

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