Szymon P. Kordon

Reexamining the activation mechanisms of adhesion G protein-coupled receptors.

Adhesion G protein-coupled receptors (aGPCRs) are a unique GPCR family defined by large, modular extracellular regions (ECRs) and a conserved seven-transmembrane (7TM) domain. These domains enable aGPCRs to mediate cell-cell and cell-matrix communication, integrate mechanical and chemical signals, and regulate diverse...