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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Sze-Man Chan

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Open access Jul 2026

Tumor-derived annexin A1 drives lenvatinib resistance by regulating SOX2/STAT3/S100A6 feedback loop and M2 macrophage polarization in hepatocellular carcinoma

The critical role of HCC-derived ANXA1 regulates lenvatinib resistance both intrinsically and extrinsically is demonstrated, and Targeting the SOX2/ANXA1/STAT3/S100A6 positive loop may provide a novel therapeutic strategy for HCC treatment.

Catherine Yu Jia Gu, C. Leung, R. Leung et al. · 0 citations

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