How conserved proteins acquire new physiological functions is a central question in molecular evolution. Rather than inventing new architectures, evolution often repurposes existing scaffolds, preserving core structural features while retuning the molecular logic that connects mechanism to physiology. Membrane transpor...
Adriana Bizior, Ming-Yu Qin, Peter Henderson et al.· bioRxiv· 0 citations
Nitrification is a major process in the global nitrogen cycle, initiated by the oxidation of ammonia to nitrite. The ammonia-oxidising bacterium Nitrosomonas europaea catalyses this first and rate-limiting step and depends on ammonium both as an energy substrate and as a nitrogen source, making ammonium acquisition cen...
Benjamin F. Cooper, Adriana Bizior, Reza Talandashti et al.· bioRxiv· 1 citation
The theoretical, computational and cultural challenges that need to be overcome to gain an understanding of the biological mesoscale are described and potential solutions are offered.
Sarah Harris, Gianluca Lattanzi, Angelo Rosa et al.· Biophysical Journal· 0 citations
It is argued that near-term value is most likely to come from disciplined workflow integration rather than wholesale replacement of classical methods, and quantum computing will become scientifically valuable when it demonstrably reduces uncertainty in computed energies, rates, spectra, or materials stability after the...
Bruno Camino, C. R. Catlow, J. Buckeridge et al.· 0 citations
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